Endocrine Abstracts

We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. EAS soluble extracts were obtained after defatting the S. cordatum<...

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) (Myrtaceae) leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (OA) and ursolic acid (UA). For the bioactive compounds to have potential in diabetes management, they should also alleviate or prevent complications of diabetes mellitus; kidney function and cardiovascular disorders. This study i...

The hypoglycaemic effect of Syzygium (i) cordatum (i) leaf extract was studied in non-diabetic and streptozotocin (STZ)-induced diabetic rats. The crude was subjected to column chromatography and spectroscopic analysis. Non-diabetic and STZ-diabetic rats were orally administered glucose (1.4 g.100 kg-1 (super -1) body weight) followed by extract (6 mg.100-1g (super -1) body weight). Weekly plasma glucose and terminal hepatic glycogen concentrations were recorded in control STZ...